I love the description of Lygate and how he comes to his profession: until he discovers medicine everything comes easy and knowledge is something you just display. Medicine isn't about position for him but his position in Middlemarch cannot help but be part of the issue: hence his plan "to do good small work for Middlemarch, and great work for the world." And his admirer Rosamond - of course her provincial ambition is filtered through him. I love the description of her infatuation: "a stranger was absolutely necessary to Rosamond's social romance," which had always turned on a lover and bridegroom who was not a Middlemarcher." For young people, so often the idea of romance is that idea of being someone else, of being someplace else. But the unevenness between the girl who pours all of that into the young doctor, and the doctor who finds her fetching but is more taken with his book on Fever, leaves us with our narrator pitying them both.
And Dorothea! You start off wondering how she will slowly become disenchanted with her marriage, and instead we have her breaking down into sobs on her honeymoon- the realization comes all at once, as the husband sucks the life out of Rome. Every provincial has that moment of realizing that, if you're looking through the wrong eyes, all the art and culture that was supposed to take you somewhere else can't take you anywhere, but it's robbed you of the fantasy of escape.